Shouheng Sun
Brown University

Synthesis and Applications of FePt and Their Composite Nanoparticles

Location: EB1 Room 1011

Friday, April 26th 2013 - 11:00 am

Recently chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) were found to release Fe in a low pH environment. The released Fe catalyzes H2O2 decomposition into reactive oxygen species within cells, causing fast oxidation and deterioration of cellular membrane. Functionalized with luteinizing hormone-releasing hormone (LHRH) peptide via phospholipid, the fcc-FePt NPs can bind preferentially to the human ovarian cancer cell line (A2780) that over-expresses LHRH receptors, and exhibit high toxicity to these tumor cells. The work demonstrates that fcc-FePt NPs may function as a new type of agent for imaging and controlled cancer therapy. The fcc-FePt can be further coated over other noble metal and core/shell Pd/FePt (Au/FePt) NPs have been synthesized. The uniform FePt shell is formed by controlled nucleation of FePt in the presence of Pd (or Au) NPs at designated reaction temperatures. The Pd/FePt NPs show the FePt shell-dependent catalytic properties and those with the 1 nm FePt shell exhibit a drastic increase in catalytic activity (12 times increase in mass current and a 130 mV gain in onset potential compared to the commercial Pt catalyst) and durability for oxygen reduction reaction. These M/FePt core/shell NPs are promising new catalysts for practical fuel cell applications.

North Carolina State University