Thom LaBean
Dept. of Materials Science & Engineering,
NC State University

Self-Assembling Molecular Materials for Applications in Bionanofabrication and Medicine

Location: EB1 Room 1011

Friday, October 14th 2016 - 11:00 am

We are developing bioinspired materials, designed to self-assemble using programmed molecular recognition, for a variety of biomedical applications as well as for fabrication of nanoelectronic devices. We use structural DNA nanotechnology to organize proteins, peptides, inorganic nanoparticles (metals, oxides, carbon, and semiconductors), nucleic acid aptamers, and chemical moieties into materials with micron-scale dimensions and nanometer-scale feature resolution. Recent results will be presented showing our ability to regulate blood coagulation, affect cell signaling pathways, and probe cell adhesion forces. We will also demonstrate a new chemical quenching method for monitoring supramolecular folding pathways, and describe diblock polypeptides capable of solution compatibilization of diverse building blocks to maximize assembly yields. Finally, we will introduce preliminary aerogel materials containing imbedded device networks being developed for eventual use as 3D integrated neural-like networks for information processing.

North Carolina State University