Roy & Diana Vagelos Laboratorie, Dept. of Chemistry
University of Pennsylvania
A Materials Genome Approach to Complex Systems and Synthetic Methods
Location: EB1 Room 1011
Friday, September 13th 2013 - 11:00 am
A materials genome approach to the design of programmed primary structures of self-assembling dendrons, dendrimers and other building blocks that are instructed to undergo intramolecular and intermolecular self-assembly, self-organization and the other sequences of events involved in the emergence of complex chiral functional systems will be presented. Materials genome uses the first principles commonly employed in biology to design the tertiary structure responsible for a particular function. Since the mechanism of transfer of structural information is not understood, and also according to the definition of complex systems, theoretically the primary structures responsible for the creation of complex functional systems characterized by adaptation, selfcontrol, self-organization, emergence, self-repair and memory, cannot be designed. This lecture will first introduce the generational and deconstruction library approaches to the discovery, prediction and design of dendron and dendrimer primary structures responsible for the generation of a tertiary structure. Subsequently these primary structures will be used to demonstrate their synthetic capabilities by changing the chemical reactivity and chemoselectivity that subsequently will be used in the design of new concepts in polymerization methodology and nanomechanical functions. Additional examples of new fundamental concepts in supramolecular electronics, transmembrane proteins that act as Aquaporin mimics, address the role of chirality in functional materials, and provide new hypothesis for the origins of chirality will follow. Finally mimics of biological cell membranes and their use in biomedical applications including glycan-ligands for sugar-binding proteins (lectins), and drug delivery devices will also be discussed. Elaboration of novel synthetic methods via the same principles will be discussed.