Thom LaBean
Professor

- 919-515-2204
- thlabean@ncsu.edu
- Engineering Building I (EB1) 3030D
- Visit My Website
- View CV
LaBean earned his BS in biochemistry from the Honors College at Michigan State University, and his PhD in biochemistry from the University of Pennsylvania. He studied protein design as a postdoctoral fellow at Duke University. He then ran his own group as research professor with appointments in the departments of Computer Science, Chemistry, and Biomedical Engineering at Duke. LaBean joined MSE@NCSU in 2011. Throughout his career, LaBean has studied the structure, evolution, and engineering of biopolymers (biomacromolecules and materials assembled from them). Current research projects involve the design, construction, and testing of self-assembling DNA nanostructures for applications in nanomedicine, molecular materials, and biomimetic fabrication of nanoelectronics.
Education
Biochemistry
University of Pennsylvania
Biochemistry
Michigan State University
Research Description
Dr. LaBean's research interests include biomolecular engineering, molecular materials, bionano science, molecular recognition and self-assembly.
Publications
- Modeling and characterization of stochastic resistive switching in single Ag2S nanowires
- Frick, N., Hosseini, M., Guilbaud, D., Gao, M., & LaBean, T. H. (2022), SCIENTIFIC REPORTS. https://doi.org/10.1038/s41598-022-09893-4
- Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits
- Gao, M., Krissanaprasit, A., Miles, A., Hsiao, L. C., & LaBean, T. H. (2021), APPLIED SCIENCES-BASEL, 11(5). https://doi.org/10.3390/app11052245
- Multivalent Aptamer-Functionalized Single-Strand RNA Origami as Effective, Target-Specific Anticoagulants with Corresponding Reversal Agents
- Krissanaprasit, A., Key, C. M., Froehlich, K., Pontula, S., Mihalko, E., Dupont, D. M., … LaBean, T. H. (2021, April 21), ADVANCED HEALTHCARE MATERIALS. https://doi.org/10.1002/adhm.202001826
- Self-Assembling Nucleic Acid Nanostructures Functionalized with Aptamers
- Krissanaprasit, A., Key, C. M., Pontula, S., & LaBean, T. H. (2021). [Review of , ]. CHEMICAL REVIEWS. https://doi.org/10.1021/acs.chemrev.0c01332
- Genetically Encoded, Functional Single-Strand RNA Origami: Anticoagulant
- Krissanaprasit, A., Key, C., Fergione, M., Froehlich, K., Pontula, S., Hart, M., … LaBean, T. H. (2019), ADVANCED MATERIALS, 31(21). https://doi.org/10.1002/adma.201808262
- 2precise coating of a wide range of DNA templates by a protein polymer with a DNA binding domain
- Hernandez-Garcia, A., Estrich, N. A., Werten, M. W. T., Van Der Maarel, J. R. C., LaBean, T. H., Wolf, F. A., … Vries, R. (2017), ACS Nano, 11(1), 144–152. https://doi.org/10.1021/acsnano.6b05938
- Engineered diblock polypeptides improve DNA and gold solubility during molecular assembly
- Estrich, N. A., Hernandez-Garcia, A., Vries, R., & LaBean, T. H. (2017), ACS Nano, 11(1), 831–842. https://doi.org/10.1021/acsnano.6b07291
- Search for effective chemical quenching to arrest molecular assembly and directly monitor dna nanostructure formation
- Majikes, J. M., Nash, J. A., & LaBean, T. H. (2017), Nanoscale, 9(4), 1637–1644. https://doi.org/10.1039/c6nr08433h
- pH-driven actuation of DNA origami via parallel I-motif sequences in solution and on surfaces
- Majikes, J. M., Ferraz, L. C. C., & LaBean, T. H. (2017), Bioconjugate Chemistry, 28(7), 1821–1825. https://doi.org/10.1021/acs.bioconjchem.7b00288
- Activatable tiles for compact robust programmable molecular assembly and other applications
- Majumder, U., Garg, S., LaBean, T. H., & Reif, J. H. (2016), Natural Computing, 15(4), 611–634. https://doi.org/10.1007/S11047-015-9532-3
Grants
- NCBC TRG: Preclinical Animal Studies for RNA Origami-Based Anticoagulant
- NC Biotechnology Center(2/15/21 - 1/15/23)
- Production Scale-up of RNA Origami-Based Anticoagulants Prior to Clinical Testing
- NC Biotechnology Center(11/30/-1 - 10/15/20)
- A multiscale material approach to understanding the effects of viscoelasticity on cell adhesion, migration, and TGF-beta activation/signaling
- National Science Foundation (NSF)(9/01/18 - 8/31/22)
- EAGER: SHF: Three-Dimensional Electronics Integration Facilitated by Molecular Assembly
- National Science Foundation (NSF)(9/15/17 - 8/31/19)
- Collaborative Research: BMAT: Adapting Cas9 Protein from CRISPR as a Structural Unit for Molecular Assembly
- National Science Foundation (NSF)(7/01/17 - 6/30/21)
- Collaborative Research: Photonic and Electronic Devices Based on Self-Assembling DNA Templates
- National Science Foundation (NSF)(7/15/16 - 6/30/20)
- BME: DNA Origami for Investigating and Reprogramming Cell Signaling
- National Science Foundation (NSF)(5/15/16 - 4/30/20)
- IRES: Vertically Integrated Team for Structural DNA NanoTech in Denmark
- National Science Foundation (NSF)(5/01/16 - 4/30/20)
- Development of 3D Electronic Materials from Self-Assembling DNA Gels
- NCSU Faculty Research & Professional Development Fund(7/01/14 - 6/30/15)
- International: Renewal for Duke - Aarhus DNA NanoTech Collaboration
- National Science Foundation (NSF)(6/01/12 - 8/31/14)