Elizabeth Loboa

Dean, University of Missouri

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Dr. Loboa is Dean of the College of Engineering and a Professor of Bioengineering at the University of Missouri, Columbia, and an Adjunct Professor in the Department of Materials Science and Engineering at NCSU.   Research in her laboratory focuses on two areas:  1) empirical and computational approaches to quantitatively determine and deliver biomimetic mechanical, electrical, and material stimuli to human stem cells for functional tissue engineering of musculoskeletal tissues; and, 2) nanofibrous “smart bandages” as controlled release systems for wound healing and tissue engineering applications requiring antimicrobial, antibacterial, and/or anti-inflammatory treatment. Her research has been funded by the Nonwovens Cooperative Research Center (NC based industry consortium), North Carolina Biotechnology Center, National Science Foundation, and the National Institutes of Health.  She is a recipient of the Ralph E. Powe Junior Faculty Award (2005), Sigma Xi Faculty Research Award (2009), UK-US Stem Cell Collaboration Development Award (2009), Stanford University Distinguished Alumni Scholar Award (2010), the NCSU Chancellor’s Innovation Award (2011), and the NCSU Faculty Scholar Award (2012).

Education

Ph.D. 2002

Mechanical Engineering

Stanford University

M.S.E. 1997

Biomechanical Engineering

Stanford University

B.S. 1995

Mechanical Engineering

University of California, Davis

Research Description

Dr. Loboa's research interests include Regenerative Medicine, Functional Tissue Engineering, Wound Healing, and Mechanobiology of Human Stem Cells.

Publications

Evidence for Aryl hydrocarbon Receptor-Mediated Inhibition of Osteoblast Differentiation in Human Mesenchymal Stem Cells
Watson, A. L. T. D., Nordberg, R. C., Loboa, E. G., & Kullman, S. W. (2019), TOXICOLOGICAL SCIENCES, 167(1), 145–156. https://doi.org/10.1093/toxsci/kfy225
Industrial-scale fabrication of an osteogenic and antibacterial PLA/silver-loaded calcium phosphate composite with significantly reduced cytotoxicity
Cai, S., Pourdeyhimi, B., & Loboa, E. G. (2019), JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 107(4), 900–910. https://doi.org/10.1002/jbm.b.34185
Primary Cilia Exhibit Mechanosensitivity to Cyclic Tensile Strain and Lineage-Dependent Expression in Adipose-Derived Stem Cells
Bodle, J., Hamouda, M. S., Cai, S., Williams, R. B., Bernacki, S. H., & Loboa, E. G. (2019), SCIENTIFIC REPORTS, 9. https://doi.org/10.1038/s41598-019-43351-y
Mechanical Stimulation of Adipose-Derived Stem Cells for Functional Tissue Engineering of the Musculoskeletal System via Cyclic Hydrostatic Pressure, Simulated Microgravity, and Cyclic Tensile Strain
Nordberg, R. C., Bodle, J. C., & Loboa, E. G. (2018), In ADIPOSE-DERIVED STEM CELLS: METHODS AND PROTOCOLS, 2ND EDITION (Vol. 1773, pp. 215–230). https://doi.org/10.1007/978-1-4939-7799-4_18
Characterizing effects of 3D-bioplotted polycaprolactone (PCL) scaffold geometry on human adipose-derived stem cell viability and proliferation
Mehendale, S., Mellor, L., Taylor, M., Loboa, E., & Shirwaiker, R. (2017), Rapid Prototyping Journal, 23(3), 534–542. https://doi.org/10.1108/rpj-03-2016-0035
Creation and evaluation of new porcine model for investigation of treatments of surgical site infection
Mohiti-Asli, M., Risselada, M., Jacob, M., Pourdeyhimi, B., & Loboa, E. G. (2017), Tissue Engineering. Part C, Methods, 23(11), 795–803. https://doi.org/10.1089/ten.tec.2017.0024
Electrical cell-substrate impedance spectroscopy can monitor age-grouped human adipose stem cell variability during osteogenic differentiation
Nordberg, R. C., Zhang, J. L., Griffith, E. H., Frank, M. W., Starly, B., & Loboa, E. G. (2017), Stem Cells Translational Medicine, 6(2), 502–511. https://doi.org/10.5966/sctm.2015-0404
Ibuprofen loaded pla nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo
Mohiti-Asli, M., Saha, S., Murphy, S. V., Gracz, H., Pourdeyhimi, B., Atala, A., & Loboa, E. G. (2017), Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 105(2), 327–339. https://doi.org/10.1002/jbm.b.33520
A novel ultrasound technique for non-invasive assessment of cell differentiation
Huang, W. B., Kim, J., Kim, K., Bakshi, S., Williams, J., Matthieu, P., … Jiang, X. N. (2016), IEEE Sensors Journal, 16(1), 61–68. https://doi.org/10.1109/jsen.2015.2477340
Cell signaling in tenocytes: Response to load and ligands in health and disease
Wall, M. E., Dyment, N. A., Bodle, J., Volmer, J., Loboa, E., Cederlund, A., … Banes, A. J. (2016), Metabolic Influences on Risk for Tendon Disorders, 920, 79–95.

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Grants

Development of a Functional Osteochondral Replacement Graft: 3-d Tissue Engineering and Biomimetic Stem Cell Guidance
Orthopaedic Research and Education Foundation(7/01/15 - 6/30/18)
Integrin Function in Cartilage
National Institutes of Health (NIH)(3/17/15 - 3/16/16)
Crosstalk Between Subchondral Bone and Articular Cartilage in Reduced Gravity May Contribute to Catastrophic Joint Damage
National Aeronautics & Space Administration (NASA)(12/01/14 - 11/30/15)
Induction of Early Stages of Osteoarthritis after Exposure to Microgravity
National Space Biomedical Research Institute (NSBRI)(6/01/13 - 2/28/15)
Human Adipose-Derived Stem Cells for Nonunion Bone Regeneration
Orthopaedic Trauma Association (OTA)(1/01/13 - 12/31/13)
Development and Translation of Controlled Release "Smart Bandages" for Antimicrobial, Antibacterial, and Anti-Inflammatory Wound Healing Applications
NC Biotechnology Center(9/01/13 - 8/31/15)
IDR: Primary Cilia as Sensors of Electric Field During Electrical Stimulation Induced hASC Osteogenesis
National Science Foundation (NSF)(1/01/12 - 12/31/16)
The National Textile Center: Electrospun Core-Sheath Fibers For Soft Tissue Engineering (F05-NS04)
NCSU National Textile Center Program(4/01/08 - 3/31/09)
Tensile Strain-Induced Osteogenesis of Human Mesenchymal Stem Cells in 3D Culture
National Institutes of Health (NIH)(12/01/09 - 1/31/13)
The Role of Palladin in the Mechanobiology of Human Mesenchymal Stem Cells
NC Biotechnology Center(6/01/07 - 5/31/10)